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HBOT Evidence Digest · Pacific Hyperbarics

TBI & Post-Concussion Syndrome

FDA status

Off-label

Evidence

Grade B · Good

Coverage

Self-pay

ICD-10

Summary

Growing trial evidence for persistent post-concussive symptoms — honestly graded, honestly explained.

Typical protocol

1.5–2.0 ATA × 60 min × 40 sessions

The evidence (2)

  1. [1] Hyperbaric oxygen therapy for post-concussion syndrome: contradictory conclusions from a controlled trial

    POSITIVE

    Harch PG, Andrews SR, Fogarty EF, et al. · Medical Gas Research · 2017 · n=63 · PMID 29119011

    Reported improvements in post-concussive symptoms and cognition with HBOT, while noting the field's ongoing controversy over sham-pressure control groups also improving.

    Quality: Positive signal but part of a contested literature — read alongside null trials.

  2. [2] The effect of hyperbaric oxygen on symptoms after mild traumatic brain injury

    NULL

    Wolf G, Cifu D, Baugh L, et al. · Journal of Neurotrauma · 2012 · n=50 · PMID 22908998

    Randomized sham-controlled military trial in which both the HBOT and sham groups improved similarly, suggesting the benefit seen in some studies may not be specific to oxygen at pressure.

    Quality: Important negative/null counterweight in the TBI debate.

Prepared by Pacific Hyperbarics · pacifichyperbarics.com · (619) 423-8200. Evidence grade reflects our editorial reading of the cited literature, last reviewed July 2026. Educational summary for clinicians — not a treatment directive. Verify coverage criteria against current payer policy.