HBOT Evidence Digest · Pacific Hyperbarics
TBI & Post-Concussion Syndrome
FDA status
Off-label
Evidence
Grade B · Good
Coverage
Self-pay
ICD-10
—
Summary
Growing trial evidence for persistent post-concussive symptoms — honestly graded, honestly explained.
Typical protocol
1.5–2.0 ATA × 60 min × 40 sessions
The evidence (2)
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[1] Hyperbaric oxygen therapy for post-concussion syndrome: contradictory conclusions from a controlled trial
POSITIVEHarch PG, Andrews SR, Fogarty EF, et al. · Medical Gas Research · 2017 · n=63 · PMID 29119011
Reported improvements in post-concussive symptoms and cognition with HBOT, while noting the field's ongoing controversy over sham-pressure control groups also improving.
Quality: Positive signal but part of a contested literature — read alongside null trials.
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[2] The effect of hyperbaric oxygen on symptoms after mild traumatic brain injury
NULLWolf G, Cifu D, Baugh L, et al. · Journal of Neurotrauma · 2012 · n=50 · PMID 22908998
Randomized sham-controlled military trial in which both the HBOT and sham groups improved similarly, suggesting the benefit seen in some studies may not be specific to oxygen at pressure.
Quality: Important negative/null counterweight in the TBI debate.