Abstract: Traumatic brain injury (TBI) often leads to persistent neurocognitive deficits, significantly impacting the quality of life for affected individuals. This retrospective analysis sought to investigate the potential effects of hyperbaric oxygen therapy (HBOT) on chronic neurocognitive impairments in patients with post-traumatic brain injuries.

Methods and Findings: A comprehensive retrospective analysis was conducted on a cohort of post-TBI patients who underwent HBOT as part of their therapeutic intervention. Cognitive function assessments, including memory, attention, and executive function, were examined over a specified period following the completion of HBOT. The study aimed to explore any observable improvements in neurocognitive deficits.

Results: The retrospective analysis revealed notable improvements in chronic neurocognitive deficits among post-TBI patients who received HBOT. Specific domains, such as memory recall, attention span, and executive function, exhibited positive changes following the therapy. The findings suggest a potential association between HBOT and the amelioration of chronic neurocognitive impairments in post-traumatic brain injury patients.

Conclusion: This retrospective analysis provides preliminary evidence supporting the notion that hyperbaric oxygen therapy may contribute to the alleviation of chronic neurocognitive deficits in individuals with a history of traumatic brain injury. Further prospective studies and controlled trials are warranted to validate and expand upon these findings, offering insights into the potential benefits of HBOT as a therapeutic intervention for post-TBI cognitive impairments.